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Schematic diagram of alternative NLRP3 inflammasome. In human monocytes, the engagement of LPS with TLR4 causes the formation of NLRP3 and subsequently release of IL-1β and IL-18. TRIF, RIPK, FADD and caspase 8 play roles in this pathway. (The color version of the figure is available in the electronic copy of the article).
