FIG 7.
Assigning the molecular features that are positively associated with the microbial features at a P value threshold of 10−20 to the phylogenetic tree. The tree is trimmed to the taxonomic-order level. Numbers in boldface show the counts of molecules assigned to the corresponding clades. Heatmap shows −log10(P), where P is the minimal P value between the molecule and an OTU within the clade. Dereplicator+ molecular annotations for the known molecules are shown. The molecular features were extracted by MSClustering based on tandem mass spectral data and annotated by spectral library search and Dereplicator+ (level 2 and 4 metabolite identification) (46).