Figure 3.

RPO Produces Significant Cardiomyocyte Loss and Compensatory Cellular Hypertrophy of Remaining Myocytes

Examples of periodic acid-Schiff−stained myocardial tissue sections from a normal control animal (left) and an animal subjected to RPO (right) illustrate the reduction in myocyte nuclear density and increase in myocyte diameter elicited by RPO. Although RPO did not elicit a change in total LV mass, the LV mass/LVEDV was increased compared with normal control animals (n = 20), which was indicative of concentric LV remodeling in the absence of overt anatomic hypertrophy in swine subjected to RPO. Values are mean ± SEM. Abbreviations as in Figure 1.