Table 3.
Multivariate analyses of overall and cancer‐caused special survival of patients with breast cancer
| Variable | Multivariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|
| OS HR | 95% CI | P‐Value | BCSS HR | 95% CI | P‐Value | ||
| Age (years) | Age (years) | ||||||
| 35‐70 | Baseline | 35‐70 | Baseline | ||||
| <35 | 0.9767 | 0.9213‐1.0354 | 0.4290 | <35 | 0.9914 | 0.9326‐1.0538 | 0.7814 |
| ≥70 | 3.3121 | 3.2506‐3.3748 | <0.001 | ≥70 | 1.8478 | 1.8005‐1.8963 | <0.001 |
| Sex | Sex | ||||||
| Female | Baseline | Female | Baseline | ||||
| Male | 1.5298 | 1.4112‐1.6584 | <0.001 | Male | 1.2934 | 1.1553‐1.448 | <0.001 |
| Race | Race | ||||||
| White | Baseline | White | Baseline | ||||
| Black | 1.2781 | 1.247‐1.3099 | <0.001 | Black | 1.2984 | 1.2602‐1.3379 | <0.001 |
| AN/AI | 1.2703 | 1.1369‐1.4193 | <0.001 | AN/AI | 1.1988 | 1.0434‐1.3775 | 0.0105 |
| API | 0.7354 | 0.7073‐0.7647 | <0.001 | API | 0.7619 | 0.7262‐0.7993 | <0.001 |
| Marital | Marital | ||||||
| DSW | Baseline | DSW | Baseline | ||||
| Married | 0.6444 | 0.6318‐0.6573 | <0.001 | Married | 0.7483 | 0.729‐0.7682 | <0.001 |
| Single | 0.8712 | 0.8484‐0.8947 | <0.001 | Single | 0.9096 | 0.8796‐0.9406 | <0.001 |
| Stage | Stage | ||||||
| Stage 0/I | Baseline | Stage 0/I | Baseline | ||||
| Stage II | 1.6699 | 1.6305‐1.7103 | <0.001 | Stage II | 2.9902 | 2.8713‐3.114 | <0.001 |
| Stage III | 3.7727 | 3.673‐3.8751 | <0.001 | Stage III | 9.0426 | 8.673‐9.428 | <0.001 |
| Stage IV | 10.8121 | 10.4493‐11.1874 | <0.001 | Stage IV | 30.9787 | 29.5487‐32.478 | <0.001 |
| Grade | Grade | ||||||
| Grade I | Baseline | Grade I | Baseline | ||||
| Grade II | 1.1837 | 1.1494‐1.2189 | <0.001 | Grade II | 1.6902 | 1.6046‐1.7803 | <0.001 |
| Grade III | 1.5688 | 1.5215‐1.6177 | <0.001 | Grade III | 2.5914 | 2.4598‐2.7299 | <0.001 |
| Grade IV | 1.5395 | 1.4257‐1.6624 | <0.001 | Grade IV | 2.5379 | 2.3036‐2.7959 | <0.001 |
| Surgery | Surgery | ||||||
| No surgery | Baseline | No surgery | Baseline | ||||
| BCS | 0.3433 | 0.3321‐0.3548 | <0.001 | BCS | 0.3349 | 0.322‐0.3483 | <0.001 |
| Other | 0.425 | 0.4121‐0.4384 | <0.001 | Other | 0.4234 | 0.4087‐0.4386 | <0.001 |
| HRs | HRs | ||||||
| ER+/PR+ | Baseline | ER+/PR+ | Baseline | ||||
| ER+/PR‐ | 1.3344 | 1.3003‐1.3693 | <0.001 | ER+/PR‐ | 1.5644 | 1.5132‐1.6175 | <0.001 |
| ER‐/PR+ | 1.5926 | 1.4786‐1.7155 | <0.001 | ER‐/PR+ | 1.9623 | 1.8015‐2.1375 | <0.001 |
| ER‐/PR‐ | 1.7221 | 1.6837‐1.7614 | <0.001 | ER‐/PR‐ | 2.1679 | 2.1089‐2.2285 | <0.001 |
| Other | 1.4388 | 1.3878‐1.4917 | <0.001 | Other | 1.6497 | 1.5719‐1.7313 | <0.001 |
Abbreviations: AN/AI, American Indian/Alaska Native; API, Asian or Pacific Islander; BCS, breast‐conserving surgery; BCSS, breast cancer‐caused special survival; CI, confidence interval; DSW, divorced/separated/widowed; ER, estrogen receptor; HR, hazard ratio; HRs, hormone receptor status; OS, overall survival; PR, progesterone receptor.