Figure 7.

JQ1 inhibits BC growth and increases cell autophagy in vivo. Tumor bearing mice were treated with JQ1 (50 mg/kg) or with vehicle control once a day by intraperitoneal injection. Mice' body weight was checked every day (A), tumor size was measured every 3 days (B). Tumors were harvested after 2 weeks of treatment, then images were taken (C) and tumors were weighted (D). The expression of LC‐3B, p62, p‐AMPKα, p‐mTOR, p‐LKB1 and p‐ULK1 was determined by IHC. *P < 0.05 vs control