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. 2019 Jul 24;117(4):717–728. doi: 10.1016/j.bpj.2019.07.028

Figure 5.

Figure 5

Tau conformational changes are dependent upon polyP chain length. Histograms from smFRET measurements probing two different regions of 2N4R, the N-terminal domain (C17–C149) (a), and the PRR and MTBR (C149–C372) (b) in the absence or presence of 20 μM polyP of different chain lengths. At least three separate measurements of each condition/construct were made. The histograms shown are representative. PIE-FRET was used for tauC17–C149 with 20 μM polyP300 (∗). The statistical analysis of repeat measurements is given in Table S4. To see this figure in color, go online.