Figure 6.

PolyP accelerates tau aggregation in a chain-length-dependent manner. The time to reach half the signal plateau (T_1/2) of tau fragments (a) measured by thioflavin T fluorescence comparing polyP chain lengths and heparin for 4R (b) and 3R (c) and comparing different fragments for polyP₃₀₀ (d) and polyP₁₄ (e). Autocorrelation curves of 4R in the presence of 1 mM polyP₃₀₀ (f) or polyP₁₄ (g). The individual autocorrelation curves are shown and their average is the thick line. The statistical analysis of repeat measurements for the thioflavin T fluorescence assays is given in Table S5. To see this figure in color, go online.