Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug 21;10:1930. doi: 10.3389/fmicb.2019.01930

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Spencer, Deng, Patras, Burcham, Sanches, Nagao and Doran.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Cas9 regulates two component system response regulator CiaR, which contributes to GBS persistence within the vaginal tract. (A) Total number of dysregulated genes between COH1Δcas9 and COH1ΔciaR strains at each mid-log phase by Venn diagram. Venn diagram on the left indicate number of genes that are up-regulated in the Δcas9 or ΔciaR mutants compared to WT COH1 and Venn diagrams on the right indicate number of genes that are down-regulated in the Δcas9 or ΔciaR mutants compared to WT COH1. Three biological replicates were analyzed for each strain. (B) Bacterial load of COH1 and COH1ΔciaR mutant in the vaginal tracts of CD-1 outbred (n = 20/group) over time. Two-way repeated measures ANOVA with Sidak’s multiple comparisons, ^∗p < 0.05; ^∗∗∗p < 0.001.