Table 3.

Poisson regression for impact of continuous glycated haemoglobin (HbA_1c) and categories on severe hypoglycaemic events

Population/analysis and comparison	Relative risk (95% CI)	P value
Swediabkids main: from first available hypoglycaemia data 2008 onwards with HbA1c counted from earliest 1 year before first registration of hypoglycaemic data n/N (%) events 1398/13413 (10.4)
HbA1c AUC category*:
By 1% increase	0.79 (0.75 to 0.83)	<0.001
6.5-6.9% v 6.5-6.9%	1.00 (Ref)
<6.5% v 6.5-6.9%	1.34 (1.09 to 1.64)	0.005
7.0-7.4% v 6.5-6.9%	0.88 (0.74 to 1.06)	0.19
7.5-8.6% v 6.5-6.9%	0.83 (0.71 to 0.98)	0.03
>8.6% v 6.5-6.9%	0.53 (0.43 to 0.64)	<0.001
Swediabkids first sensitivity analysis, main including those participants with onset date on or after first registration of hypoglycaemic data n/N (%) events725/8271 (8.8%)
By 1% increase	0.88 (0.81 to 0.96)	0.003
6.5-6.9% v 6.5-6.9%	1.00 (Ref)
<6.5% v 6.5-6.9%	1.30 (1.04 to 1.63)	0.02
7.0-7.4% v 6.5-6.9%	0.91 (0.73 to 1.14)	0.40
7.5-8.6% v 6.5-6.9%	0.96 (0.78 to 1.18)	0.68
>8.6% v 6.5-6.9%	0.79 (0.56 to 1.12)	0.18
Swediabkids second sensitivity analysis−first sensitivity+including only those participants from the main retinopathy/albuminuria analyses n/N (%) events: 217/1359 (16.0%)
By 1% increase	0.75 (0.64 to 0.88)	<0.001
6.5-6.9% v 6.5-6.9%	1.00 (Ref)
<6.5% v 6.5-6.9%	2.10 (1.32 to 3.34)	0.002
7.0-7.4% v 6.5-6.9%	0.86 (0.55 to 1.34)	0.51
7.5-8.6% v 6.5-6.9%	0.91 (0.62 to 1.36)	0.66
>8.6% v 6.5-6.9%	0.58 (0.31 to 1.10)	0.10

AUC=area under the curve.

^*<6.5% (<48 mmol/mol); 6.5-6.9% (48-52 mmol/mol); 7.0-7.4% (53-57 mmol/mol); 7.5-8.6% (58-70 mmol/mol); >8.6% (>70 mmol/mol).