Table 4.
Performance of highly sensitive rapid diagnostic test by age
| ≤5 years | 5 to < 10 years | 10 to < 18 years | 18 to < 40 years | 40–90 years | |
|---|---|---|---|---|---|
| %, n/N (95% CI) |
%, n/N (95% CI) |
%, n/N (95% CI) |
%, n/N (95% CI) |
%, n/N (95% CI) |
|
| PCR prevalence |
10.7%, 67/626 (8.3–13.1) |
12.7%, 105/824 (10.5–15.2) |
14.5%, 119/823 (12.1–16.9) |
13.8%, 121/874 (11.6–16.1) |
13.1, 81/619 (10.4–15.7) |
| Sensitivity |
17.9%, 12/67 (8.7–27.1) |
43.8%, 46/105 (34.3–53.3) |
43.7%, 52/119 (34.8–52.6) |
40.5%, 49/121 (31.7–49.2) |
39.5%, 32/81 (28.9–50.2) |
| Specificity |
93.0%, 520/5599 (90–95.1) |
87.1%, 626/719 (84.6–89.5) |
84.5%, 597/704 (81.8–87.6) |
87.9%, 662/753 (85.6–90.3) |
91.8%, 494/538 (89.5–94.1) |
| Positive predictive value |
23.5%, 12/51 (11.9–35.2) |
33.1%, 46/139 (25.3–40.9) |
32.7%, 52/159 (25.4–39.9) |
35.0%, 49/140 (27.1–42.9) |
42.1%, 32/76 (31.0–53.2) |
| Negative predictive value |
90.4%, 520/575 (88.03–92.8) |
91.4%, 626/685 (89.3–93.4) |
89.9%, 597/664 (87.6–92.2) |
90.2%, 662/734 (88.03–92.3) |
90.9%, 494/543 (88.6–93.4) |
| Comparison of HS-RDT sensitivity of older children and adults to children < 5 years | 1 | χ2 = 12.3, p < 0.01 | χ2 = 12.6, p < 0.01 | χ2 = 10, p < 0.01 | χ2 = 8.2, p < 0.01 |