Fig. 1.

Histological features of peritoneal samples obtained from the different groups stained with Masson Trichrome (× 200). There were no morphological alterations in mesothelial, submesothelial or muscle cells in the Control group (a) or in animals with advanced CKD (b). CG induced marked thickening of the submesothelial peritoneal membrane, a change characterized by increased cellularity and collagen deposition, in the PF (c) and PF/CKD groups (d). Uremic rats with PF treated with TAM (e) or rBMP7 (f) exhibited preserved peritoneal membrane, as demonstrated via quantitative analysis (g). Overall ANOVA p < 0.0001. Post-test p-values: *p < 0.01 vs Control; ^#p < 0.01 vs CKD, ^†p < 0.01 vs PF, ^§p < 0.01 vs PF/CKD