Fig. 2.

Metformin could attenuate the formation of Ang II-induced AAA in ApoE^−/−mice. a Ultrasound was used to detect the maximum diameter of abdominal aorta in mice. b The abdominal aorta of mice in each group were removed surgically after 28 days of infusion and photographed. c The morphological changes of abdominal aorta in each group were observed using HE staining, EVG staining, Masson staining and Sirius Red Staining. d Tunel staining was used to detect the aortic tissue apoptosis. e Immunohistochemistry staining was used to observe the expression of CD31, CD68, MMP-2, and MMP-9 in aortic tissue