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. 2019 Aug 28;17:291. doi: 10.1186/s12967-019-2042-9

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — IDH2 inhibition decreased exocrine function and the expression of several key genes. a The levels of growth hormone were 78 ± 15.3 and 72.3 ± 13.7 mIU/m and the levels of IGF-l 74.5 ± 12.7 and 63.4 ± 15.3 mIU/m after shRNA C and D plasmid blockage in GH3 cell lines. a The mRNA of E-cadherin in shRNA C and D plasmid knockdown group was 3.18 and 4.28 folds of that in control group, and N-cadherin 0.47 and 0.24 folds, and MMP2 0.35 and 0.22 folds. c The mRNA of IL-6 in shRNA C and D plasmid knockdown group was 0.65 and 0.26 folds of that in control group, and STAT3 0.34 and 0.24 folds, and STAT5 0.41 and 0.23 folds. All assays were performed in triplicate. **Compared to control, p < 0.01. *Compared to control, p < 0.05