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. 2019 Aug 28;7:139. doi: 10.1186/s40478-019-0792-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Telomere alterations are associated with overall survival in NF1-associated glioma and MPNST. Kaplan-Meier curves and log rank tests demonstrate worse overall survival in patients with ALT-positive NF1-gliomas compared to patients with ALT-negative NF1-gliomas (p < 0.0001) (a). Additionally, overall survival was intermediate for patients with tumors with long telomeres (but lacking ALT), and longer for patients with tumors with normal telomeres (p = 0.0021) (b). In the MPNST cohort known to be NF1-associated, the survival difference between ALT-positive and ALT-negative tumors was not statistically significant (p = 0.11) (c). However, overall survival was inferior for tumors with ALT, intermediate for tumors with normal telomeres, and superior for tumors with short telomeres (p = 0.0052), when further subdivided (d)