Table 3.
Association of telomere lengths with overall survival in patients with NF1-associated MPNST
| Univariate | Multivariate | |||||||
|---|---|---|---|---|---|---|---|---|
| Death/Censor | Person-time (months) | HR | (95% CI) | P-value | HR | (95% CI) | P-value | |
| Age | 16/25 | 1482 | 1.01 | (0.98–1.04) | 0.5 | 1.08 | (1.02–1.14) | 0.006 |
| Grade | ||||||||
| Low | 1/3 | 168 | 1.00 | (Ref) | – | 1.00 | (Ref) | – |
| High | 15/22 | 1315 | 2.29 | (0.30–17.52) | 0.3 | 12.33 | (0.42–28.97) | 0.03 |
| Telomere lengths | ||||||||
| Normal | 6/10 | 417 | 1.00 | (Ref) | – | 1.00 | (Ref) | – |
| Short | 1/13 | 801 | 0.13 | (0.02–1.12) | 0.06 | 0.03 | (0.01–0.29) | 0.003 |
| ALT | 9/2 | 264 | 1.93 | (0.68–5.49) | 0.2 | 1.21 | (0.41–3.59) | 0.7 |