Table 3.
Clinical and demographic characteristics in patients with and without HCC occurrence—univariate and multivariate analysis
| Parameters | Univariate analysis | Multivariate analysis (cirrhosis) | Multivariate analysis (Child–Pugh) | ||||
|---|---|---|---|---|---|---|---|
| Patients without HCC (n = 950) | Patients with HCC (n = 35) | p | O.R. [95% C.I.] | p | O.R. [95% C.I.] | p | |
| Male gender, n (%) | 518 (54.5) | 25 (71.4) | 0.048 | 2.852 [1.162–6.999] | 0.022 | 2.738 [1.109–6.762] | 0.029 |
| Age, years, median [IQR] | 67 [59–73] | 69 [64–74] | 0.045 | ||||
| BMI, kg/m2, median [IQR] | 26 [24–28.4] | 25.4 [23.4–28] | 0.17 | ||||
| Presence of diabetes, n (%) | 121 (12.8) | 10 (28.6) | 0.007 | 0.392 [0.155–0.988] | 0.047 | 0.369 [0.146–0.931] | 0.047 |
| Presence of cirrhosis, n (%) | 696 (73.4) | 35 (100) | 0.002 | 0.153 [0.019–1.239] | 0.079 | ||
| CTP B classa n (%) | 72/696 (10.3) | 10/34 (29.4) | 0.001 | 0.430 [0.170–1.086] | 0.074 | ||
| HCV genotype 1, n (%) | 724 (77.3) | 29 (82.9) | 0.44 | ||||
| 24 weeks treatment duration, n (%) | 354 (37.3) | 19 (54.3) | 0.041 | ||||
| Baseline HCV-RNA, UI/ml, median [IQR] | 995,500 [350,000–2,646,500] | 729,000 [290,000–1,238,000] | 0.123 | ||||
| Liver stiffness, kPa, median [IQR] | 14.9 [11.8–22] | 32 [18.5–44.4] | < 0.0001 | 1.048 [1.020–1.077] | 0.001 | 1.057 [1.031–1.084] | 0.000 |
| SVR12, n (%) | 933 (98.2) | 33 (94.3) | 0.09 | ||||
| DAA-SOF based, n (%) | 707 (74.6) | 31 (88.6) | 0.09 | ||||
| DAA-RBV included, n (%) | 690 (72.8) | 15 (42.9) | < 0.0001 | ||||
| DAA-SOF + RBV, n (%) | 562 (59.2) | 12 (34.3) | 0.003 | ||||
| DAA-SOF without RBV, n (%) | 145 (20.5) | 19 (61.3) | 0.003 | 15.363 [6.668–35.396] | 0.000 | 0.059 [0.025–0.137] | 0.000 |
aComputed based on number of cirrhotic patients