Fig. 2.

Number of DE miRNAs in kidney biopsy tissues of three CKD groups. a The expression of these miRNAs in three CKD groups is illustrated in the heatmap (n = 4 in each group). The miRNAs with fold change > 1.5 and p-value < 0.05 for expression in CKD patients compared to normal control were considered as differentially expressed (DE). b Venn diagram has shown the number of upregulated miRNAs in three CKD groups. Forty miRNAs were elevated in CKD patients compare to normal control. c The number of downregulated miRNAs in three CKD groups. Seventy-six miRNAs were decreased in CKD groups compare to normal. MCD: minimal change disease; FSGS: focal segmental glomerulosclerosis; DN: diabetic nephropathy; Con: normal kidney tissues from healthy donor