Table 2.
Contingency table analysis of risks for clinical outcomes among the functional indices as recorded in the study patients. Data are presented as relative risk [95% CI] (p value)
| Variable | Outcome | |||
|---|---|---|---|---|
| Hypercapnia | Nocturnal hypoventilation | NIV start within 6 months | Death within 12 months | |
| ΔTmax > 0.75 | 3.3 [1.14–6.72] (0.01) | 3.11 [1.03–8.64] (0.03) | 2.1 [1.09–4.5] (0.01) | 2.5 [1.15–5.4] (0.02) |
| ΔTdi Vt < 20% | 1.7 [1.02–3.4] (0.04) | 2 [1.03–4-44] (0.01) | 2.0 [1.08–5.3] (0.03) | 2.6 [0.87–5.4] (0.2) |
| SNIP < 40 cmH2O | 4.2 [1.9–6.9] (< 0.001) | 2.9 [1.05–4.9] (0.005) | 1.7 [1.3–5.5] (0.001) | 1.6 [1.16–6.5] (0.04) |
| FVC < 50% | 3.2 [1.2–7] (0.006) | 3 [1.1–7.5] (0.01) | 1.8 [1.2–3.4] (0.01) | 2.2 [1.04–6.4] (0.03) |
Legend: ΔTmax ratio between diaphragm thickness at the end of tidal volume and after maximal inspiration, ΔTdi Vt change in diaphragm thickness during spontaneous breathing at tidal volume, SNIP Sniff Inspiratory Nasal Pressure, FVC Forced Vital Capacity