Table 3.
Multivariate analysis comparing characteristics of cases and controls with variables stratified by terciles
| Variable | Cases, n (%) | Controls, n (%) | OR (95%CI) a | p | OR (95%CI) b | p |
|---|---|---|---|---|---|---|
| A1AT (mg/dl) | ||||||
| Low: < 138 | 27 (24.7) | 41 (49.4) | 1 (−) | 1 (−) | ||
| Medium: ≥138 and < 167 | 32 (29.3) | 32 (38.5) | 1.49 (0.66–3.39) | 0.34 | 0.96 (0.38–2.45) | 0.94 |
| High: ≥167 | 50 (45.9) | 10 (12) | 7.33 (2.80–19.24) | < 0.001 | 3.60 (1.23–10.53) | 0.019 |
| Cholesterol (mg/dl) | ||||||
| Low: < 168 | 40 (36.7) | 18 (21.7) | 2.91 (1.43–5.94) | 0.003 | 2.91 (1.08–7.85) | 0.03 |
| Medium: ≥168 and < 200 | 44 (40.4) | 25 (30.1) | 3.73 (1.74–8.00) | 0.001 | 3.03 (1.09–8.41) | 0.03 |
| High: ≥200 | 25 (22.9) | 40 (48.2) | 1 (−) | 1 (−) | ||
| Neutrophils (per μl) | ||||||
| Low: < 4007 | 22 (20.2) | 45 (54.2) | 1(−) | 1 (−) | ||
| Medium: ≥4007 and < 5955 | 42 (38.5) | 25 (30.1) | 3.35 (1.65–6.84) | 0.001 | 2.95 (1.14–7.60) | 0.02 |
| High: ≥5955 | 45 (41.3) | 13 (15.7) | 7.08 (3.18–15.77) | < 0.001 | 4.90 (1.60–14.94) | 0.005 |
OR: odds-ratio; 95%CI: confidence interval of a 95%; A1AT: alpha 1-antitripsin; a OR adjusted by age and gender; b OR adjusted by age, gender, alpha 1-antitripsin, cholesterol and neutrophils