Table 3.

Receiver operating characteristic curve analyses for IL-23, IL-27, IFN-γ, and ADA in differentiating TMPE from TPE

Biomarker	Optimal cutoff	Sensitivity (%) (95% CI)	Specificity (%) (95% CI)	LR (+)	LR (−)	AUC (95% CI)	p-value
IL-23	> 53.07 pg/mL	100 (54.1–100)	88.89 (51.7–99.7)	9	1.12	0.875 (0.688–1.000)	0.001 a
IL-27	< 35.75 pg/mL	100 (59.0–100)	66.7 (22.3–95.7)	3	0.85	0.762 (0.463–1.000)	0.116
ADA	< 10.9 U/L	100 (63.1–100)	87.5 (47.4–99.7)	8	1.14	0.953 (.0850–1.000)	0.002 a
IFN-γ	< 129.9 pg/mL	100 (59.0–100)	83.33 (22.3–95.7)	6	1.2	0.952 (0.839–1.000)	0.006 a

ADA Adenosine deaminase, TMPE Talaromyces marneffei pleural effusions, ADA Adenosine deaminase, AUC Area under the curve, CI Confidence interval, IFN Interferon, IL Interleukin, LR Likelihood ratio, TPE Tuberculous pleural effusion

^a p < 0.05