Table 2.
Average parameters of P. falciparum susceptibility to chloroquine (CQ), quinine (QN), monodesethylamodiaquine (DQ), mefloquine (MQ), lumefantrine (LMF), pyronaridine (PND), piperaquine (PPQ), dihydroartemisinin (DHA), artesunate (AS) and doxycycline (DOX)
| Drugs | Isolates from Senegal (n = 86) | African isolates from imported malaria analyzed for pfcarl (n = 173) | ||||||
|---|---|---|---|---|---|---|---|---|
| IC50 | Geometric mean | Resistance % | IC50 | Geometric mean | Resistance % | |||
| Min | Max | Min | Max | |||||
| CQ | 0.6 | 954.9 | 60.0 | 48.6 | 6.27 | 791.6 | 69.7 | 28.3 |
| QN | 5 | 1429.8 | 113 | 5.7 | 5.29 | 690.1 | 127.8 | 0 |
| DQ | 1.6 | 227.3 | 21.7 | 23.6 | 1.9 | 196.43 | 29.2 | 8.1 |
| MQ | 2 | 109.2 | 24.8 | 48.5 | 4.4 | 173.43 | 39.5 | 67.7 |
| LMF | 0.5 | 82.9 | 4.53 | 0 | 0.33 | 16.66 | 1.4 | 0 |
| PND | 0.4 | 116.6 | 16.4 | 3.1 | 0.8 | 122.96 | 16.5 | 6.1 |
| PPQ | 3.2 | 241.9 | 37.4 | 6.1 | 0.94 | 137.51 | 34.3 | 0.6 |
| DHA | 0.08 | 17.28 | 1.36 | 1.5 | 0.09 | 28.11 | 4.1 | 17.5 |
| AS | 0.06 | 18.06 | 2.18 | 3.5 | 0.1 | 23.56 | 3.7 | 9.8 |
| DOX | 0.9 | 121.6 | 23.0 | 28.2 | 0.46 | 41.14 | 16.2 | 17.3 |
IC50 in nM for CQ, QN, DQ, MQ, LMF, PND, PPQ, DHA, AS
IC50 in µM for DOX