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. 2019 Aug 28;16:34. doi: 10.1186/s12014-019-9255-z

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Graphical representation of differentially-expressed plasma proteins between all CRC stages (I–IV) compared to healthy controls. a Box plots for differentially-expressed proteins between healthy control and CRC stages I–IV. *p < 0.05, **p < 0.005, ***p < 0.0005 and ****p < 0.0001 calculated using unpaired t-tests. Distribution (b) of 31 potential candidates identified from four biomarker discovery experiments superimposed on the SWATH reference library protein concentration curve plotted against protein abundance rank. The color key on the top-right side shows proteins identified from different biomarker discovery experiments