Table 3.
Summary of lead SNP (LD clumped) that show suggestive associations (P < 10−5) with phenylephrine average infusion rate in a meta-analysis
| Lead SNP | Coordinate (GRCh37) | A1/A2 | MAF | Beta-meta (CI95) | P-PhaseI | P-PhaseII | P-meta | Gene | Upstream gene | Downstream gene |
|---|---|---|---|---|---|---|---|---|---|---|
| rs2069661 | 5:75916615 | A/C | 0.01725 | 13.85 (8.65~19.04) | 5.71E−06 | 1.15E−02 | 1.80E−07 | F2RL2, IQGAP2 | LOC101929109 | NCRUPAR |
| rs77080086 | 1:66727250 | T/C | 0.02468 | 11.07 (6.81 ~ 15.33) | 5.50E−07 | 1.97E−01 | 3.51E−07 | PDE4B | LOC101927139 | LOC105378776 |
| rs11572377 | 1:41943795 | C/G | 0.01689 | 13.00 (7.89 ~ 18.11) | 5.44E−05 | 3.41E−03 | 6.09E−07 | EDN2 | RNA5SP45 | |
| rs145738725 | 15:25826461 | A/G | 0.01304 | 14.46 (8.49~20.42) | 2.50E−04 | 1.44E−03 | 2.06E−06 | LOC105370737 | ATP10A | |
| rs77948500 | 12:60298988 | C/G | 0.01074 | − 15.85 (− 22.39~− 9.31) | 1.82E−06 | 2.29E−01 | 2.06E−06 | LOC100996696 | PGBD3P1 | |
| rs148501690 | 6:87012360 | A/G | 0.01437 | − 13.88 (− 19.61~− 8.15) | 2.33E−03 | 5.65E−05 | 2.06E−06 | NDUFA5P9 | LOC100652960 | |
| rs4234482 | 3:139844245 | C/G | 0.26610 | − 3.64 (− 5.15~− 2.14) | 6.24E−04 | 4.11E−04 | 2.16E−06 | CLSTN2 | NMNAT3 | LOC105374132 |
| rs74400620 | 7:121002702 | A/T | 0.01364 | 13.98 (8.13~19.8) | 1.61E−06 | 8.51E−01 | 2.83E−06 | FAM3C | WNT16 | CYCSP19 |
| rs2071336 | 16:12061674 | A/G | 0.03253 | 8.82 (5.04~12.59) | 2.41E−05 | 8.37E−02 | 4.72E−06 | TNFRSF17 | LOC729978 | SNX29 |
| rs76054107 | 5:26671351 | T/C | 0.02113 | 10.76 (6.09~15.42) | 1.39E−04 | 1.27E−02 | 6.11E−06 | MSNP1 | CCNB3P1 | |
| rs16835559 | 3:130749602 | A/C | 0.01467 | 12.47 (6.96~17.98) | 1.48E−05 | 2.01E−01 | 9.19E−06 | NEK11 | ASTE1 | LOC339874 |
| rs1940556 | 14:88661112 | T/C | 0.01916 | − 10.95 (− 15.80~− 6.10) | 9.94E−05 | 3.62E−02 | 9.58E−06 | KCNK10 | LOC105370612 | SPATA7 |