Table 4.
Summary of the results for the top 3 variants from the association testing
| SNP | Average infusion rate | Resistant vs. sensitive | Resistant vs. (sensitive + intermediate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Phase I (N = 1205) | Phase II (N = 329) | Phase I (N = 589) | Phase II (N = 147) | Phase I (N = 1205) | Phase II (N = 329) | |||||||
| β | P | β | P | OR | P | OR | P | OR | P | OR | P | |
| rs2069661 (F2RL2) | 13.71 (7.81~19.6) | 5.71E−06 | 14.32 (3.28~25.4) | 0.012 | 3.50 (1.52~8.05) | 3.19E−03 | 1.84 (0.26~13.18) | 0.545 | 3.90 (1.97~7.70) | 9.12E−05 | 2.28 (0.43~12.22) | 0.335 |
| Sex | − 4.05 (− 6.34~− 1.76) | 5.44E−04 | 1.44 (− 2.87~5.74) | 0.513 | 0.50 (0.33~0.75) | 7.97E−04 | 0.59 (0.25~1.35) | 0.210 | 0.71 (0.50~1.03) | 0.068 | 1.00 (0.48~2.08) | 0.995 |
| Age | 0.08 (− 0.01~0.17) | 0.078 | 0.16 (− 0.01~0.32) | 0.065 | 0.97 (0.96~0.99) | 2.58E−03 | 0.99 (0.95~1.02) | 0.429 | 1.01 (0.99~1.02) | 0.335 | 1.00 (0.97~1.03) | 0.974 |
| Body weight | 0.14 (0.09~0.19) | 6.84E−08 | 0.18 (0.09~0.27) | 1.19E−04 | 1.01 (1.00~1.02) | 0.019 | 1.02 (0.99~1.04) | 0.139 | 1.01 (1.01~1.02) | 4.40E−04 | 1.01 (0.997~1.03) | 0.112 |
| SNPxWeight | 0.33 (0.08~0.57) | 9.26E−03 | 0.05 (− 0.75~0.85) | 0.895 | 1.01 (0.98~1.05) | 0.512 | 1.04 (0.90~1.21) | 0.581 | 1.02 (0.99~1.06) | 0.172 | 1.02 (0.91~1.15) | 0.695 |
| rs77080086 (PDE4B) | 12.17 (7.43~16.91) | 5.50E−07 | 6.43 (− 3.32~16.2) | 0.197 | 1.40 (0.69~2.8) | 0.35 | 1.59 (0.33~7.57) | 0.562 | 1.75 (0.93~3.30) | 0.082 | 1.7 (0.40~7.21) | 0.468 |
| Sex | − 3.81 (− 6.09~− 1.53) | 1.08E−03 | 1.10 (− 3.24~5.45) | 0.620 | 0.51 (0.34~0.77) | 1.09E−03 | 0.55 (0.24~1.26) | 0.155 | 0.74 (0.51~1.06) | 0.098 | 0.95 (0.46~1.97) | 0.899 |
| Age | 0.07 (− 0.02~0.02) | 0.115 | 0.16 (− 0.01~0.33) | 0.060 | 0.97 (0.96~0.99) | 2.20E−03 | 0.99 (0.95~1.02) | 0.459 | 1.01 (0.99~1.02) | 0.387 | 1.00 (0.97~1.03) | 0.943 |
| Body weight | 0.14 (0.09~0.19) | 5.69E−08 | 0.18 (0.09~0.27) | 8.74E−05 | 1.01 (1.00~1.02) | 0.016 | 1.02 (0.996~1.04) | 0.125 | 1.01 (1.01~1.02) | 4.42E−04 | 1.01 (0.998~1.03) | 0.096 |
| SNPxWeight | − 0.05 (− 0.26~0.17) | 0.679 | 0.36 (− 0.40~1.11) | 0.354 | 0.99 (0.96~1.02) | 0.641 | 0.99 (0.90~1.09) | 0.832 | 1.00 (0.98~1.03) | 0.953 | 1.00 (0.91~1.11) | 0.995 |
| rs11572377 (EDN2) | 12.26 (6.32~18.2) | 5.44E−05 | 15.14 (5.08~25.19) | 3.41E−03 | 3.95 (1.30~11.97) | 0.015 | 5.97 (1.35~26.32) | 0.018 | 2.03 (0.97~4.25) | 0.047 | 4.3 (1.28~14.63) | 0.018 |
| Sex | − 4.05 (− 6.32~− 1.78) | 4.86E−04 | 0.88 (− 3.40~5.17) | 0.687 | 0.52 (0.35~0.78) | 1.72E−03 | 0.54 (0.23~1.26) | 0.151 | 0.72 (0.50~1.04) | 0.079 | 0.9 (0.45~1.94) | 0.848 |
| Age | 0.078 (− 0.01~0.17) | 0.086 | 0.17 (0.01~0.03) | 0.038 | 0.97 (0.96~0.99) | 4.42E−03 | 1.00 (0.96~1.02) | 0.526 | 1.01 (0.99~1.02) | 0.335 | 1.0 (0.97~1.03) | 0.862 |
| Body weight | 0.13 (0.08~0.18) | 3.28E−07 | 0.18 (0.09~0.27) | 1.32E−04 | 1.01 (1.00~1.02) | 0.021 | 1.02 (0.998~1.04) | 0.068 | 1.01 (1.01~1.02) | 7.83E−04 | 1.0 (0.997~1.03) | 0.110 |
| SNPxWeight | 0.01 (− 0.22~0.24) | 0.96 | − 0.26 (− 0.61~0.10) | 0.155 | 1.05 (0.97~1.12) | 0.219 | 0.97 (0.88~1.06) | 0.479 | 1.01 (0.98~1.03) | 0.613 | 0.96 (0.91~1.01) | 0.120 |
The effect sizes for SNP, sex, age, and body weight were the main effect size in linear or logistic regression models for the quantitative or categorical traits respectively. The effect size of SNP × Weight was the effects of the interaction terms in the models which include only the SNP, body weight, and their interaction. Regression β and odds ratio (OR) were presented as mean (95% confidence interval)