Table 1.
Summary of M. tb transcriptional profiles in physiologically relevant environments encountered during establishment of infection.
| Association | Gene category | Sputum (a) | AEC (b) | HIV-blood (c) | HIV+blood (c) | Act mac (d) | RPE (e) |
|---|---|---|---|---|---|---|---|
| Active replication | 30S (23) |
 (6) |
 (5) |
NDE | NDE |
 (13) |
(3) |
| 50S (36) |
(16) |
(5) |
NDE | NDE |
(16) |
(4) (1) |
|
| ATP Synthase (8) |
(7) |
 (8) |
NDE | NDE |
(7) |
NDE | |
| Aerobic respiration | NADH-D1 (14) |
(6) |
(7) |
NDE | NDE |
(6) |
(3) (2) |
| Cytochrome C Reductase (3) |
(2) |
(2) |
NDE | NDE |
(2) |
(1) (1) |
|
| Cytochrome C Oxidase |
(1) |
(1) |
(1) |
(1) |
(2) |
(1) |
|
| Dormancy/ Stress | DosR Regulon (48) |
(6) |
 (26) |
(3) |
(21) |
 (41) |
(13) |
| Universal Stress Proteins (9) | NDE |
(5) |
NDE |
(4) |
(7) |
(4) |
|
| Resuscitation | Resuscitation Promoting Factors (5) |
(2) |
(2) |
NDE |
(1) |
NDE |
(1) |
| Persistence | mprA (Rv0981) | |
NDE | NDE | |
NDE | NDE |
| Virulence/ ESAT-6 Secretion | ESX-1 (20) |
(5) |
(1) |
(4) |
(6) |
(2) |
(3) (1) |
| Iron acquisition | ESX-3 (11) |
(5) |
(6) |
NDE | NDE |
(3) |
(2) |
| Virulence/PE/ PPE Secretion | ESX-5 (17) |
(4) |
NDE |
(1) |
(5) |
NDE |
(6) (1) |
| Virulence/ Dissemination | esat-6 (Rv3875) | |
|
|
|
|
|
| Unknown | Encodes ESAT-6-like Proteins (23) |
(8) |
(6) |
(2) |
(8) |
(1) |
(14) |
Green (down) arrows indicate down-regulation. Red (up) arrows indicate upregulation. Numbers of arrows indicate the extensiveness of differential expression. Numbers in parentheses indicate number of genes within the category or the number of genes differentially expressed. NDE, not differentially expressed. Reference in all studies was M. tb logarithmically-growing in laboratory media. Studies cited (a) (Sharma et al., 2017) (b) (Ryndak et al., 2015) (c) (Ryndak et al., 2014) (d) (Schnappinger et al., 2003) (e) (Abhishek et al., 2018). (AEC, human type 2 AEC, A549 cell line; Act Mac, activated murine bone marrow derived macrophages; RPE, human retinal pigmented epithelial cells, ARPE-19 cell line).