Table 4. . Tricarboxylic acid cycle inhibitors.

Inhibitor	Target	IC50
		Protein	Cell
22	MDH1/2	1–5 μM	1–20 μM
23	mIDH	<50 nM	<50 nM
24	mIDH	<100 nM	N.D.R.
25	mIDH	<100 nM	N.D.R.
26	mIDH	<100 nM	<100 nM
27	mIDH	<10 nM	<10 nM
28	mIDH	<10 nM	<100 nM
29	mIDH	<100 nM	<10 nM
30	mIDH	0.6 nM	N.D.R.
31	mIDH	536 nM	N.D.R.
32	mIDH	1–2 nM	N.D.R.
33	mIDH	12 nM	8 nM
34	mIDH	<20 nM	6.7 nM
35	mIDH	5.7 nM	0.2 nM
36	mIDH	3 nM	N.D.R.
37	mIDH	<300 nM	N.D.R.
38	mIDH	7 nM	∼20 nM
39	mIDH	<10 μM	∼20 μM

Summary of inhibitory potencies of compounds inhibiting steps in the tricarboxylic acid cycle. Values marked as approximate (∼) were generally read off a graph, while exact values were generally reported in a table. For values marked as ‘N.D.R.’, no data were reported for that compound. ‘Protein’ IC₅₀ values were generally determined in systems with recombinant or otherwise purified proteins, while ‘Cell’ IC₅₀ values generally apply to the inhibition of cancer cell growth, or a similar cellular readout.

MDH: Malate dehydrogenase; mIDH: Mutant isocitrate dehydrogenase.