Table 5. . Nutrient import inhibitors.

Inhibitor	Target	IC50
		Protein	Cell
40	GLUT5	100 μM	N.D.R.
41	GLUT4	18.2 μM	13.4 μM
42	GLUT1	25–40 nM	80–700 nM
43	GLUT1	∼3 μM	1–8 μM
44	GLUT1	336 nM	N.D.R.
45	GLUT1	37 nM	N.D.R.
46	LAT1	36–131 μM	110 nM
47	ASCT2	240–310 nM†	N.D.R.
48	ASCT2	9.6 μM	∼10–50 μM

Summary of inhibitory potencies of compounds inhibiting steps in the tricarboxylic acid cycle. Values marked as approximate (∼) were generally read off a graph, while exact values were generally reported in a table.

^†Reported as a K_i rather than an IC₅₀. For values marked as ‘N.D.R.’, no data were reported for that compound. ‘Protein’ IC₅₀ values were generally determined against the ability of the transmembrane protein to transport its target molecule into a cell, while ‘Cell’ IC₅₀ values generally apply to the inhibition of cancer cell growth, or a similar cellular readout.