Table 4.

Time-varying hazard ratios of recurrence-free survival at select follow-up times for competing interventions vs observation, Stage III.

Months	HR vs observation (95% CrI)
	Pembrolizumab	Ipilimumab	Biochemotherapy	Interferon-α2a	Interferon-α2b (12 months)	Interferon-α2b (24 months)	Pegylated Interferon-α2b
3	0.62 (0.50–0.77)*	0.80 (0.64–1.00)	0.34 (0.18–0.65)*	0.74 (0.51–1.07)	0.46 (0.29–0.71)*	0.75 (0.51–1.13)	0.80 (0.65–1.00)
6	0.51 (0.41–0.65)*	0.76 (0.63–0.91)*	0.47 (0.30–0.73)*	0.85 (0.66–1.10)	0.61 (0.45–0.84)*	0.78 (0.59–1.03)	0.83 (0.71–0.98)*
9	0.46 (0.35–0.61)*	0.74 (0.61–0.89)*	0.56 (0.38–0.82)*	0.93 (0.73–1.17)	0.73 (0.56–0.96)*	0.79 (0.61–1.03)	0.85 (0.74–0.98)*
12	0.43 (0.32–0.58)*	0.72 (0.58–0.89)*	0.64 (0.44–0.92)*	0.98 (0.76–1.26)	0.83 (0.64–1.08)	0.80 (0.61–1.05)	0.87 (0.75–1.00)
15	0.40 (0.29–0.57)*	0.71 (0.56–0.90)*	0.70 (0.48–1.03)	1.03 (0.78–1.34)	0.91 (0.70–1.20)	0.81 (0.60–1.09)	0.88 (0.75–1.02)
18	0.39 (0.27–0.56)*	0.70 (0.54–0.91)*	0.76 (0.51–1.14)	1.06 (0.79–1.43)	0.99 (0.74–1.32)	0.82 (0.59–1.13)	0.88 (0.75–1.04)
21	0.37 (0.25–0.55)*	0.69 (0.52–0.92)*	0.81 (0.53–1.26)	1.10 (0.80–1.51)	1.05 (0.78–1.44)	0.82 (0.58–1.17)	0.89 (0.75–1.06)
24	0.36 (0.23–0.54)*	0.69 (0.51–0.93)*	0.86 (0.55–1.38)	1.13 (0.80–1.59)	1.12 (0.81–1.56)	0.83 (0.57–1.20)	0.90 (0.75–1.08)

^*Statistically significant results.