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. 2019 Aug 9;8(1):1648995. doi: 10.1080/20013078.2019.1648995

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Glioblastoma-derived EVs bind Siglec-9, not DC-SIGN. (a). Siglec-binding ELISA on U87-derived EVs adsorbed to a solid phase. Screen for binding of recombinant Siglec-3, −7, −9 and −10 constructs (N = 3). (b). Absence of calcium-dependent DC-SIGN binding to ligands on U87-derived EVs by DC-SIGN binding ELISA on a titration of EVs adsorbed to a solid phase (N = 3). (c-d). DC-SIGN binding to polyacrylamide (PAA)-coupled Le^X and -Le^Y glycoconjugates by DC-SIGN binding ELISA on titrations of PAA-Le^X and PAA-Le^Y adsorbed to a solid phase (N = 3). (e). Schematic representation of possible uptake of glioblastoma EVs by DCs via Siglec 9, not DC-SIGN.