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. Author manuscript; available in PMC: 2019 Dec 13.
Published in final edited form as: J Phys Chem B. 2018 Oct 9;122(49):11695–11701. doi: 10.1021/acs.jpcb.8b07773

Figure 4.

Figure 4.

Desolvation in the binding region and interdomain gap. (A) Regions considered in the analysis, defined by spheres of radius 6 Å (red) or 18 Å (orange), illustrated for D = 9.5 Å. (B) Distribution of “desolvated” volumes, calculated as in eq 2, for MDM2–p53 (top) or barnase–barstar (bottom), in the binding regions (left) or in the interdomain gap (right).