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. 2019 Aug 7;26(1):820–830. doi: 10.1080/10717544.2019.1636423

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Cellular uptake, trafficking pathway and internalization investigation on RAW264.7 cells: (A) cellular uptake of free Tri, Tri-BLs and HA@Tri-BLs at different incubation time quantified by the intracellular Tri content (Statistically, paired t-test, **p < .01, significantly different each other); (B) relative uptake rate of HA@Tri-BLs in the presence of various cytosis inhibitors compared to the control (no inhibitor); and (C) cell internalization of Tri-BLs and HA@Tri-BLs characterized by CLSM (Statistically, paired t-test, **p < .01, significantly different from the control).