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. Author manuscript; available in PMC: 2019 Aug 28.
Published in final edited form as: Cell Rep. 2019 Aug 6;28(6):1526–1537.e4. doi: 10.1016/j.celrep.2019.06.098

Figure 1. Sample Cohort Summary.

Figure 1.

(A) For our discovery set, mammary cell preparations (MCPs) were isolated from caudal glands of 12-week-old NRL-PRL females (MCPs A–E, n = 5). Nulliparous mice with matched end-stage tumors (T) and adjacent aged mammary glands (AMGs) were collected following development of spontaneous ER+ tumors (15–20 months; T1–T5, AMG1–AMG5, n = 5). All samples were examined by RNA-seq. Tumors and matched tail DNA samples underwent WGS and WES.

(B) In our extension set, we evaluated 22 additional tumors from NRL-PRL females (T6–T27) and 4 cell lines (derived from 2 independent tumors).

(C) Summary of samples interrogated in this study. The number of mice associated with each group or the sample identifiers are indicated in parentheses. *Four cell lines were derived from 2 additional independent tumors (2 each).

See Table S1 for further details.