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. 2019 Aug 28;14(8):e0221798. doi: 10.1371/journal.pone.0221798

Fig 3. Histologic and functional changes in diabetic mouse hearts.

Fig 3

(A) Optical microscopic findings. a,b: H&E stained control and DM mouse sections. c, d: MT stained control and DM mouse sections. e, f: PAS stained control and DM mouse sections. g, h: TUNEL stained control and DM mouse sections. No evidence of tissue injury, such as inflammation, sarcomere disruption, apoptosis, necrosis, or fibrosis (x200), was observed. (B) Transthoracic echocardiogram of control (left panel) and the STZ-induced diabetic mice hearts (right panel). LV internal dimensions at diastole; LVIDd, LV internal dimension at systole; LVIDs, LV ejection fraction; LVEF, fractional shortening; FS. (C) Analysis of echocardiogram measurements. a: LVIDd (mm), b; LVIDs (mm), c; LVEF (%), d: FS (%), e: LV mass (g), f: heart/total body weight ratio. [abbreviations: LVIDd, left ventricular internal dimension at diastole; LVIDs, left ventricular internal dimension at systole; LVEF, left ventricular ejection fraction; FS, fractional shortening].