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. 2019 Aug 28;14(8):e0221798. doi: 10.1371/journal.pone.0221798

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© 2019 Lee et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 7 — a~d: Electron microscopic analysis of control and diabetic heart tissues. a: This image shows well-organized sarcomeres and mitochondria in control heart tissues (x12000). b: The image shows small, fragmented mitochondria among sparse and widened sarcomeres in diabetic mouse heart (x10000). c: Image showing damaged, ruptured mitochondria with discharges (arrow) and fissuring of mitochondria (arrowheads) at high resolution in a diabetic mouse heart (x25000). d: The degrees of mitochondrial damage (as assessed using our semi-quantitative scoring system) were related to the NTT-MMP-2.