Table II.
Clinicopathologic characteristics related to miRNA expression in patients with metastatic breast cancer.
| Variables | Patients n=9 | miR-4485-3p Mean ± SD | miR-1273a Mean ± SD | miR-361-3p Mean ± SD | miR-342-3p Mean ± SD | miR-200c-3p Mean ± SD | miR-301a-3p Mean ± SD |
|---|---|---|---|---|---|---|---|
| Age | |||||||
| ≤53 | 6 | 7.94±6.51 | 22.28±12.20 | 10.67±11.77 | 35.55±35.39 | 34.025±47.18 | 17.93±25.33 |
| >53 | 3 | 3.33±3.85 | 13.13±6.63 | 7.59±7.68 | 31.14±13.43 | 23.85±7.68 | 6.29±8.76 |
| P-value | 0.38 | 0.39 | 0.9 | 0.71 | 0.71 | 0.54 | |
| Smoking | |||||||
| Positive | 3 | 10.32±6.39 | 28.57±9.99 | 21.86±8.35 | 18.56±8.50 | 18.67±5.81 | 6.12±3.82 |
| Negative | 6 | 4.44±5.16 | 14.46±8.92 | 3.53±1.91 | 41.84±32.97 | 36.61±46.36 | 17.28±25.78 |
| P-value | 0.16 | 0.09 | 0.02 | 0.38 | 0.9 | 1 | |
| Treatment | |||||||
| Hormone therapy | 4 | 7.56±5.077 | 20.23±8.33 | 7.57±6.105 | 39.70±41.39 | 41.19±58.93 | 18.26±32.83 |
| Chemotherapy | 5 | 5.47±7.02 | 18.31±13.95 | 6.105±11.30 | 29.58±18.01 | 22.18±7.65 | 9.79±7.18 |
| P-value | 0.55 | 0.55 | 1 | 0.9 | 0.55 | 0.73 | |
| HER2 | |||||||
| Positive | 2 | 9.79±11.03 | 23.89±22.54 | 16.24±21.56 | 29.99±29.31 | 24.01±1.20 | 13.54±4.74 |
| Negative | 7 | 5.43±4.70 | 17.815±8.47 | 7.75±6.49 | 35.25±30.99 | 32.52±43.48 | 13.56±24.42 |
| P-value | 0.5 | 1 | 1 | 1 | 0.5 | 0.33 | |
| Menarche | |||||||
| >12 years | 4 | 11.14±5.47 | 29.36±8.31 | 18.10±10.16 | 19.87±7.42 | 15.98±7.16 | 5.15±3.67 |
| ≤12 years | 5 | 2.61±2.86 | 11.00±3.12 | 2.87±1.16 | 45.45±35.51 | 42.35±49.39 | 20.28±27.62 |
| P-value | 0.03 | 0.01 | 0.01 | 0.41 | 0.41 | 0.7 | |
| Site of metastasis | |||||||
| Liver | |||||||
| Positive | 2 | 11.59±8.49 | 32.48±10.39 | 24.58±9.76 | 17.62±7.81 | 7.88±3.25 | 7.88±3.25 |
| Negative | 7 | 5.54±5.03 | 15.75±9.22 | 5.67±5.60 | 18.56±9.88 | 6.46±7.91 | 6.46±7.91 |
| P-value | 0.42 | 0.14 | 0.7 | 1 | 0.64 | 0.64 | |
| Lung | |||||||
| Positive | 2 | 10.29±6.41 | 26.78±12.30 | 17.55±14.00 | 12.70±6.74 | 14.08±8.26 | 5.49±4.74 |
| Negative | 7 | 4.46±5.18 | 15.35±9.29 | 5.68±5.59 | 44.77±30.05 | 38.91±44.91 | 17.59±25.54 |
| P-value | 0.26 | 0.16 | 0.26 | 0.02 | 0.26 | 0.71 | |
| Mediastinum | |||||||
| Positive | 2 | 2.97±3.23 | 12.59±5.88 | 6.20±6.93 | 49.60±36.43 | 48.23±53.98 | 21.75±31.39 |
| Negative | 7 | 9.14±6.49 | 24.42±12.04 | 12.39±12.25 | 21.67±15.39 | 16.55±11.03 | 7.00±6.34 |
| P-value | 0.19 | 0.11 | 0.55 | 0.11 | 0.28 | 0.73 | |
| Bone | |||||||
| Positive | 1 | 7.39±8.78 | 22.39±13.24 | 5.17±2.29 | 62.24±54.34 | 68.51±85.67 | 34.88±46.13 |
| Negative | 8 | 6.12±5.84 | 18.24±11.50 | 10.92±11.35 | 26.03±16.69 | 19.81±8.44 | 7.46±7.11 |
| P-value | 1 | 0.66 | 1 | 0.33 | 0.88 | 0.66 | |
| Cervical ganglia | |||||||
| Positive | 3 | 2.61±2.86 | 11.00±3.12 | 2.87±1.16 | 45.45±35.51 | 42.35±49.39 | 20.28±27.62 |
| Negative | 4 | 11.14±5.47 | 29.36±8.31 | 18.10±10.16 | 19.87±7.42 | 15.98±7.16 | 5.15±3.67 |
| P-value | 0.03 | 0.01 | 0.01 | 0.41 | 0.41 | 0.73 |
| Variables | miR−4459 Mean ± SD | miR-200b-3p Mean ± SD | miR-3182 Mean ± SD | miR −141-3p Mean ± SD | miR-7-5p Mean ± SD | miR-187-3p Mean ± SD |
|---|---|---|---|---|---|---|
| Age | ||||||
| ≤53 | 5.92±6.36 | 5.50±4.85 | 1,245.80±1,623.86 | 53.52±52.01 | 16.54±21.12 | 2.09±4.22 |
| >53 | 0.41±0.72 | 9.50±5.05 | 1,976.99±2,681.96 | 15.85±1.32 | 3.98±3.31 | 0.31±0.55 |
| P-value | 0.08 | 0.26 | 0.9 | 0.16 | 0.38 | 0.67 |
| Smoking | ||||||
| Positive | 8.65±8.80 | 3.85±2.99 | 903.56±338.08 | 24.04±7.53 | 4.86±1.54 | 0.30±0.53 |
| Negative | 1.80±1.73 | 8.32±5.34 | 1,782.52±2,318 | 49.09±54.96 | 16.10±21.50 | 2.10±4.21 |
| P-value | 0.35 | 0.38 | 0.54 | 0.9 | 0.54 | 0.47 |
| Treatment | ||||||
| Hormone therapy | 1.89±2.21 | 6.83±5.24 | 453.168±247.04 | 43.61±58.49 | 18.66±26.72 | 2.66±5.32 |
| Chemotherapy | 5.84±7.32 | 6.83±5.44 | 2,318.62±2,276.15 | 38.44±39.20 | 7.30±5.92 | 0.57±0.52 |
| P-value | 0.53 | 0.9 | 0.28 | 1 | 1 | 0.68 |
| HER2 | ||||||
| Positive | 9.79±11.03 | 5.83±3.00 | 2,565.25±2,691.15 | 69.44±53.67 | 10.76±8.67 | 0.96±0.04 |
| Negative | 2.46±3.12 | 7.12±5.61 | 1,182.18±1,752.23 | 32.54±43.72 | 12.80±20.36 | 1.65±3.98 |
| P-value | 0.29 | 0.88 | 0.5 | 0.22 | 0.66 | 0.26 |
| Menarche | ||||||
| >12 years | 7.34±7.65 | 3.73±2.45 | 760.75±397.20 | 24.26±6.16 | 6.77±4.00 | 0.23±0.46 |
| ≤12 years | 1.48±1.73 | 9.31±5.33 | 2,072.55±2,466.90 | 53.92±60.00 | 16.82±23.96 | 2.52±4.57 |
| P-value | 0.26 | 0.19 | 0.9 | 0.73 | 0.9 | 0.22 |
| Site of metastasis | ||||||
| Liver | ||||||
| Positive | 12.98±6.52 | 2.31±1.96 | 976.16±443.83 | 27.84±5.15 | 5.57±1.33 | 0.46±0.65 |
| Negative | 1.80±1.73 | 7.11±4.50 | 1,820.28±2,295.30 | 30.11±38.51 | 7.00±6.59 | 0.32±0.50 |
| P-value | 0.06 | 0.28 | 0.85 | 0.42 | 1 | 1 |
| Lung | ||||||
| Positive | 10.05±6.85 | 2.47±1.41 | 714.16±551.74 | 19.49±14.91 | 3.942.96 | 0.300.53 |
| Negative | 1.10±1.39 | 9.01±4.72 | 1,877.22±2,250.58 | 51.36±52.90 | 16.56±21.13 | 2.104.21 |
| P-value | 0.02 | 0.04 | 0.9 | 0.71 | 0.26 | 0.47 |
| Mediastinum | ||||||
| Positive | 0.49±0.99 | 11.10±4.28 | 1,469.77±2,016.29 | 67.36±60.17 | 19.83±26.40 | 3.15±5.02 |
| Negative | 6.96±6.48 | 3.42±1.92 | 1,505±2,027.359 | 19.44±11.26 | 6.36±4.29 | 0.18±0.41 |
| P-value | 0.03 | 0.01 | 0.9 | 0.41 | 0.73 | 0.08 |
| Bone | ||||||
| Positive | 1.70±2.40 | 8.80±7.64 | 432.07±141.03 | 77.61±74.47 | 35.25±32.21 | 5.32±7.53 |
| Negative | 4.77±6.37 | 6.27±4.69 | 1,791.66±2,071.41 | 30.20±35.18 | 5.81±5.52 | 0.411±0.51 |
| P-value | 0.65 | 0.88 | 0.5 | 0.22 | 0.11 | 0.63 |
| Cervical ganglia | ||||||
| Positive | 1.48±1.73 | 9.31±5.33 | 2,072.55±2,466.90 | 53.92±60.00 | 16.82±23.96 | 2.52±4.57 |
| Negative | 7.34±7.65 | 3.73±2.45 | 760.75±397.20 | 24.26±6.16 | 6.77±4.00 | 0.23±0.46 |
| P-value | 0.26 | 0.19 | 0.9 | 0.73 | 0.9 | 0.22 |
Values in bold font indicate statistically significant differences (P<0.05).