Scheme 3. Synthetic Route for Aldehydes 27 and 28.
Reagents and conditions: (a) CH3NHOCH3·HCl, BOP, Et3N, CH2Cl2, rt, 2 h (85–88%); (b) (Boc)2O, Et3N, DMAP, CH2Cl2 (94%); (c) DIBAL-H in hexanes (1 M), THF, −78 °C, assumed quant.
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