Table V.
Most significant GO pathway of the 32 nodes in the protein-protein interaction network.
| GO ID | Term | P-value | Associated genes |
|---|---|---|---|
| GO:0035455 | Response to interferon-α | 3.23899×10−12 | BST2, EIF2AK2, IFIT2, IFIT3, IFITM1, MX2 |
| GO:0035456 | Response to interferon-β | 8.3886×10−8 | BST2, IFITM1, PLSCR1, XAF1 |
| GO:0060337 | Type I interferon signaling pathway | 5.06394×10−27 | BST2, IFI35, IFIT1, IFIT2, IFIT3, IFITM1, IRF7, IRF9, ISG15, ISG20, MX2, OASL, RSAD2, USP18, XAF1 |
| GO:0051607 | Defense response to virus | 4.21784×10−39 | BST2, CXCL10, DDX58, DDX60, DHX58, EIF2AK2, HERC5, IFI44L, IFIH1, IFIT1, IFIT2, IFIT3, IFIT5, IFITM1, IRF7, IRF9, ISG15, ISG20, MX2, OASL, PLSCR1, RSAD2, RTP4, TRIM22 |
| GO:0045069 | Negative regulation of viral genome replication | 2.22495×10−16 | BST2, EIF2AK2, IFIT1, IFIT5, IFITM1, ISG15, ISG20, OASL, PLSCR1, RSAD2 |
| GO:0032480 | Negative regulation of type I interferon production | 3.69762×10−10 | DDX58, DHX58, HERC5, IFIH1, ISG15, UBE2L6 |
GO, gene ontology.