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. 2019 Jul 31;44(4):1484–1494. doi: 10.3892/ijmm.2019.4296

Figure 4.

Figure 4

Irradiation prior to XVir-N-31 infection delayed the growth of R28 tumor spheroids in human cortical brain slice cultures. R28mCherry spheroids were implanted in human brain slices stained with NeuO. The cultures were left either untreated (Co), irradiated with 3 Gy, infected with 5×107 IFU XVir-N-31, or were irradiated with 3 Gy and infected using 5×107 IFU XVir-N-31 24 h later. Images were captured every second day starting at the day of XVir-N-31 infection. Green staining represents NeuO staining in the brain slices. Red staining represents R28mCherry-expressing cells. Representative 1/6 spheres from 2 independent experiments is presented (scale bar=200 µm). IFU, infectious units; Co, control; Combi, 3 Gy tumor irradiation + an intratumoral XVir-N-31 injection (1.5×108 IFU) 24 h later.