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. Author manuscript; available in PMC: 2019 Aug 28.
Published in final edited form as: Mol Cancer Res. 2018 Mar 28;16(7):1092–1102. doi: 10.1158/1541-7786.MCR-18-0106

Figure 2. p53 function is required for IR-induced cytoplasmic translocation of BRCA1 and sensitization of breast cancer cells to PARPi in vivo.

Figure 2.

A and B, relative tumor volumes of mice bearing MCF7 (A) or MCF7/E6 (B) tumors treated with no treatment (Control, n = 3), 25mg/kg of ABT-888 for 5 consecutive days (ABT-888, n = 3), 3 Gy ionizing radiation (IR, n = 3), or the combination of 3 Gy IR followed by 25mg/kg ABT-888 for 5 days (ABT-888 + IR, n = 3). C and D, the percentage of cells demonstrating nuclear and nuclear plus cytoplasmic (N + NC), or primarily cytoplasmic (C) staining of BRCA1 in MCF7 control (C) and MCF7/E6 (D) tumors (n = 5 per group) harvested 24 h after treatment with 3 Gy IR. *, p < 0.05.