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. Author manuscript; available in PMC: 2019 Aug 28.
Published in final edited form as: Mol Cancer Res. 2018 Mar 28;16(7):1092–1102. doi: 10.1158/1541-7786.MCR-18-0106

Figure 3. Reduced HR-mediated DNA repair following radiation requires p53 function.

Figure 3.

A and B, HR repair was analyzed in HR-reporter MCF7 cells treated with control siRNA (siCtrl) or siRNA targeting p53 (siP53) (A) or in MCF7 cells transfected by empty vector or vector encoding R273H mutant p53 (B). C and D, the surviving fraction of MCF7 siCtrl and siP53 cells (C) or MCF7 empty vector and R273 H mutant p53 expressing cells (D) was determined by clonogenic survival assay. Cells were first treated with 0 or 4 Gy IR and then treated 24h later with 0, 5, 7.5, or 10 µM ABT-888. Results are the average of three independent experiments.