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. Author manuscript; available in PMC: 2019 Aug 28.
Published in final edited form as: ACS Nano. 2015 Mar 13;9(3):2614–2625. doi: 10.1021/nn5062707

Figure 4.

Figure 4.

Poroelastic properties of aggrecan estimated across species and ages. (a) AFM images of individual aggrecan molecule have been used to quantify structural properties such as core protein length LCP and GAG chain length LGAG (image reproduced with permission from ref 47. Copyright 2012 Elsevier). (b) GAG chain length and (c) core protein length of aggrecan varies across age and species (data from refs 28 and 47). (d) The axial stiffness Ea of adult human aggrecan is higher than that of newborn human and fetal bovine (two-way ANOVA, p < 0.05). Ea is not significantly different between newborn human and fetal bovine. (e) The hydraulic permeability k for adult human, newborn human and fetal bovine aggrecan did not show any significant differences.