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. 2019 Aug 28;5(8):eaax0801. doi: 10.1126/sciadv.aax0801

Fig. 2. Tethering siRNA to the hydrogel via UV conjugation.

Fig. 2

Schematic illustration of (A) siRNA-MA synthesis and (B) conjugation of siRNA-MA to DEX-MAES via photopolymerization and siRNA release upon hydrolytic degradation of ester and/or disulfide bonds within the DEX hydrogel. (C) Polyacrylamide gels confirming conjugation of siRNA-MA to DEX-MAES after application of UV light. SPDP, succinimidyl 3-(2-pyridyldithio) propionate; DMSO, dimethyl sulfoxide; RT, room temperature.