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. 2019 Aug 28;5(8):eaaw1822. doi: 10.1126/sciadv.aaw1822

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Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 4 — Representative sensograms (A) display interactions of MIH5 WT and MIH5-engineered mAbs (mIgG1, mIgG2a, mIgG2b, mIgA, and mIgG2a_silent) for immobilized mFcγRI, mFcγRIIb, and mFcγRIV at increasing concentrations. Binding to FcγR is expressed in resonance units (RU). SPR was performed on four different concentrations of immobilized FcγRs (1, 3, 10, and 30 nM) to determine affinity [K_d(M)] of the Fc variants for the different FcRs (B). n = 3, mean ± SEM. (C) Predicted antibody-dependent cellular cytotoxicity (ADCC) activity for each murine isotype variant on the basis of their differential affinity for FcγRs.