Fig. 5. Effects of morphogen priming of engineered mesenchymal condensations and in vivo mechanical loading on tissue-level bone regeneration.

Representative histological (A) hematoxylin and eosin and (B) Safranin-O/Fast green staining of defect tissue at week 4 (left) and week 12 (right), with stiff (top) and compliant fixation (bottom), selected on the basis of mean bone volume. Scale bars, 100 μm (×40).