Fig. 3. Rewiring of the allosteric network of PKA-CL205R upon binding VPS36.
(A) Steady-state phosphorylation kinetics of Kemptide and VPS36 peptides for PKA-CWT and PKA-CL205R. Corresponding values can be found in table S2. (B) CONCISE analysis on the apo, ATPγN, ATPγN/PKI, and ATPγN/VPS36 states of PKA-CWT and PKA-CL205R. (C) The CHESCA correlation matrix for PKA-CWT upon binding VPS36. (D) The CHESCA correlation matrix for PKA-CL205R upon binding VPS36.