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. 2019 Aug 28;5(8):eaaw9298. doi: 10.1126/sciadv.aaw9298

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Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

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Fig. 5 — (A) Correlation matrix of PKA-C^WT when bound to PKI emphasizing locations of Cushing’s mutation in relation to allosteric nodes. (B) Missing correlations for PKA-C^L205R upon binding PKI colored according to the community map of PKA-C^WT. (C) CHESCA correlation matrices for PKA-C^WT + PKI, PKA-C^L205R + PKI, and PKA-C^L205R + VPS36, respectively, plotted on the structure of PKA-C with colors specific to the community map analyses completed previously for PKA-C^WT (35). Specific communities are emphasized to highlight elements that experience the most dramatic changes in the number and extent of chemical shift covariance for PKA-C^L205R upon binding PKI and VPS36.