Skip to main content
. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Exp Eye Res. 2019 Feb 18;185:107585. doi: 10.1016/j.exer.2019.02.001

Fig. 7. AQP0 activity is differentially modulated by BFSP1 and its post-translationally modified fragments.

Fig. 7.

Full length human BFSP1 is cleaved by caspases at sites 433 and 549. The 433 site reveals a cryptic myristoylation site. The lens expresses both NMT1 and NMT2. The 434–549 and 434–665 fragments, once myristoylated, can effectively eliminate the regulation of AQP0 Pf by Ca2+. Preventing myristoylation restores the Ca2+ regulation of AQP0 Pf (right hand side of the figure).