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. Author manuscript; available in PMC: 2020 Feb 19.
Published in final edited form as: Nat Neurosci. 2019 Aug 19;22(9):1413–1423. doi: 10.1038/s41593-019-0462-8

Fig 3. CREB is an upstream regulator of the pink module.

Fig 3.

a) Binding motifs overrepresented (FDR q < 0.05) in the pink module (colored pink) with common non-overrepresented motifs (colored blue) included for comparison (top). Both significantly overrepresented binding motifs contain a CRE site (bottom). b-e) Upstream regulator analysis of transcriptional changes in pink module genes. CREB is an upstream regulator across brain regions and is predicted to be upregulated in resilience in PFC. f) mRNA levels of CREB1 in PFC from MDD patients and matched controls (two-tailed t test, t= 1.216, p = 0.232, n=17,22 mice). g) CREB1 and ZNF189 are correlated in the PFC of controls to a greater extent than in MDD subjects (ANCOVA, F1,35 = 7.702, p = 0.009, n = 17 control and 22 MDD). **p < 0.01. Bar graphs show mean ± SEM.