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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Transplantation. 2019 Sep;103(9):1821–1833. doi: 10.1097/TP.0000000000002744

Figure 7. Factors involved in coagulation and fibrinolysis.

Figure 7

(A) Circulating vWF significantly increased at 12 and 20 hours compared to baseline, but was not significantly different from sham. (B) Thrombin and (C) fibrinogen also significantly increased over baseline by 20 hours in BD animals. (D) Plasminogen significantly increased in BD animals at 12 and 20 hours compared to baseline. (E) Tissue-type plasminogen activator (tPA) showed an increase that was significant in sham animals at 20 hours compared to baseline, although a trend toward increasing tPA was evident in both groups at both 12 and 20 hours. No significant differences between groups were detected (A-E). (F) Activated partial thromboplastin time (aPTT) was significantly longer in sham groups at 12 hours, however values remained within normal ranges. (G) PT remained near baseline values and within normal ranges for all animals. A-E: BD (n=7), sham (n=5), data presented is average value normalized to albumin, +SEM. F-G: BD (n=7), sham (n=5), data presented is average value, +SEM. Time-point values within each group were compared by 1-way repeated measures ANOVA with Bonferonni correction. Differences between groups at each time-point were compared by unpaired T-test. *p<0.05, **p<0.01, ***p<0.001.