(A) Factor XII and (B) Prekallikrein remained near baseline and were not statistically different between groups. (C) Kallikrein B1 significantly decreased at 20 hours compared to baseline in BD but the trend is similar for both groups and the values are not statistically different between BD and sham. (D) C1INH significantly increased from baseline at 12 and 20 hours respectively, however the trends were similar for both groups and the values are not statistically different between BD and sham. (E) Bradykinin formation in BD was significantly elevated at 12 and 20 hours compared to baseline, however values were not significantly different from sham. A-D: BD (n=7), sham (n=5), data presented is average value normalized to albumin, +SEM. E: BD (n=6), sham (n=5), data presented is average value normalized to albumin, +SEM. Time-point values within each group were compared by 1-way repeated measures ANOVA with Bonferonni correction. Differences between groups at each time-point were compared by unpaired T-test. *p<0.05, **p<0.01.